Professor Lieberman studied chemistry at the Massachusetts Institute of Technology, graduating with a B.S. in 1989. She worked with Professor Tomikazu Sasaki at the University of Washington on the de novo design of protein structure, receiving her Ph.D. in 1994. She investigated semiconductor-liquid junction solar cells as a National Science Foundation postdoctoral fellow with Professor Nathan Lewis at the California Institute of Technology and joined the faculty of the University of Notre Dame in 1996. She was promoted to associate professor in 2002.
The group's research focuses on surface chemistry, self-assembly of two- and three-dimensional structures, and molecular electronics. A new project focuses on paper-based sensors for detection of counterfeit drugs. The main experimental techniques used are inorganic/organic synthesis, CMOS processing, and physical and analytical measurements of surface or materials properties. Scanning tunneling microscopy, atomic force microscopy, electrochemistry, X-ray photoelectron spectroscopy, and optical spectroscopy are used to get insight into the structure and electronic properties of molecules on surfaces or inside materials. The group's work is quite interdisciplinary and we collaborate with several groups in the College of Engineering
DNA origami are amazing structures that self assemble from a long template strand of DNA (usually a viral genome or plasmid) and hundreds of short synthetic oligonucleotides. You can watch an animation we made showing how DNA origami are assembled here.
We are studying fundamental materials issues for the integration of self-assembling DNA nanostructures (DNA lattices, tiles, or origami) with top-down CMOS fabrication methods. DNA-templated assembly of electronic components offers several possible wins as a patterning technology for nanoelectronics. Self-assembly of DNA can create objects on the scale of 10-100 nm as well as repeating grids or meshes that cover several square microns. Design principles are sufficiently understood such that DNA nanostructures with novel, arbitrary shapes can move from concept to reality in about 2 weeks. Students with an interest in synthetic chemistry can tackle the integration of non-DNA components with DNA nanostructures, while students with more of a physical or analytical focus can address fundamental questions about the yields, error types, and ultimate utility of self-assembly.
Guided assembly of biomolecules and nanoparticles
Electron-beam lithography is used in very high resolution CMOS fabrication processes. We are developing methodology to use the electron beam to chemically pattern a surface, and then to deposit biomolecules upon the very tiny chemical patterns. Biomolecules of interest include proteins, virus particles, and DNA.
Technology for the developing world
We are developing analytical devices to detect fake pharmaceuticals and perform other analytical tasks. Several different tests are run simultaneously on a single sample. The devices are paper based, contain all necessary reagents, do not need electricity, and can be read by taking a picture with a cell phone and sending it to a web site. The overall goal of this project is to "crowdsource" chemical analysis, revealing spatial and temporal information that will be useful for public health, forensic, and environmental applications.
"Spatial Patterning of DNA Origami with Chemically Modified Graphene Substrates," Je Moon Yun, Kyoung Nan Kim, Ju Young Kim, Dong Ok Shin, Won Jun Lee, Sun Hwa Lee, Marya Lieberman, and Sang Ouk Kim, Angew. Chem. Int. Ed. 2011, 50, 1-5.Link
"Synthesis and Characterization of a Side-by-side Phthalocyanine Dimer," Wei He and Marya Lieberman, J. Porphyrins Phthalocyanines 2011, 15, 277-292.Link
"Comparison of methods for orienting and aligning DNA origami” Kyoung-Nan Kim, Koshala Sarveswaran, Lesli Mark, and Marya Lieberman, Soft Matter 2011, 7, 4636-4643.Link
"A Low-Tech Analytical Method for Diethylcarbamazine Citrate in Medicated Salt," Abigail Weaver, Patrick Brown, Shannon Huey, Marco Magallon, E. Brennan Bollman, Dominique Mares, Thomas G. Streit, and Marya Lieberman, PLoS Negl Trop Dis. 2011 February, 5(2), e1005.Link
“Self-assembled monolayers of poly(ethylene glycol) silane as a resist for ultrahigh-resolution electron beam lithography on silicon oxide,” Bo Gao, Gary H. Bernstein and Marya Lieberman, Journal of Vacuum Science & Technology B 2009, 27, 2292-2295.Link
"Guided Deposition of Individual DNA Nanostructures on Silicon Substrates," B. Gao, K. Sarveswaran, G. H. Bernstein, M. Lieberman, Langmuir 2010, 26, 12680-12683.Link