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Rotaxanes as Highly Stable Near-IR Dyes

Progress in the nascent field of in vivo optical imaging will be greatly accelerated by the invention of new Near-IR fluorophores with improved performance in biological media. We have recently developed a series of novel squaraine-rotaxanes that are completely stable in serum. The utility of these Near-IR dyes will be demonstrated by conjugating them to cancer targeting ligands and employing the conjugates in optical imaging protocols.