Todd Houston (Griffith University)


Location: Radiation Laboratory Auditorium

"Manipulating Boron and Sugar Acid Interactions for Sensing and Catalysis"


Abstract:  Elevated levels of free sialic acid (FSA) in serum can serve as a marker for certain diseases such as cancer and alcoholism.  We have recently developed a fluorescent receptor for FSA that incorporates a unique divergent response mechanism.[1]  This dampens the signal of potentially competing ligands such as other monosaccharides.  We have now applied this to a receptor for the unique sugar acid KDO found in the LPS of gram negative bacteria.  Additionally, we have discovered a remarkably rapid amide bond forming reaction to allow rapid assembly of boron-based sensors.

[1] Levonis, S. M.; Kiefel, M. J.; Houston, T. A. Chem. Commun. 2009, 2278.